NIPH Clinical Trials Search

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国立保健医療科学院

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Number of results: 69121
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  • Comparisons of Prefrontal Inhibition and Excitation Between Prefrontal Intermittent Theta-Burst Stimulation and 10-Hz Repetitive Transcranial Magnetic Stimulation for Treating Refractory Depression: A Sham-Control Neuroimaging Study
  • The evidence so far suggests that inhibitory function, such as GABAa-receptor-related and GABAb-receptor-related inhibitory function in the DLPFC, is key to treatment responses in MDD. Prolonged intermittent theta-burst stimulation(piTBS) could be effective through the modulation of prefrontal excitatory and inhibitory function. In addition, previous literature provided the evidence that 2-weeks left-sided DLPFC-piTBS had similar antidepressant efficacy with the 4-6weeks standard left-sided DLPFC-10HzrTMS. However, the following questions remain to be answered: (1)4-weeks left-sided DLPFC-piTBS could provide better antidepressant efficacy than 4-weeks left-sided DLPFC-10HzrTMS; (2)the potentially different effects of 4-weeks piTBS and rTMS on PFC inhibitory functions, and (3) the identification of reliable biomarkers, including EEG signals, that could reliably predict the antidepressant effects of 4-weeks rTMS/piTBS intervention.
  • Taipei Veterans General Hospital, Taipei, Taiwan
  • 2024-10-28
  • Recruiting

  • ESFstudy
  • IFALD
  • Yohji Uehara
  • 2024-10-28

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