NIPH Clinical Trials Search

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国立保健医療科学院

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  • Anti-reflux treatment on Gastroesophageal reflux-related airway inflammation during exacerbating COPD patients
  • Patients with COPD coexisting GERD is associated with an increasing acute exacerbation (AECOPD) rate. Still, a causal relationship between refluxate and airway inflammation derived from airway specimens has not been reported yet. The anti-gastric acid intervention resulted in conflicting results in reducing the AECOPD rate. Non-acid refluxate might be the key, but it has not been proven yet, particularly in AECOPD patients. Prokinetic agents are an effective add-on therapy for proton pump inhibitor (PPI) poor-responding GERD. Theoretically, prokinetic agents act as a possible solution to reduce non-acid refluxate. Therefore, we hypothesize that AECOPD patients with coexisting GERD might have elevated levels of non-acid refluxate (bile acids [BAs] and pepsin) and airway inflammation profile (vs. those not coexisting GERD), and these elevated markers might have differential reduction in responding to PPI treatment with or without combined prokinetic agent.
  • Taipei Veterans General Hospital
  • 2024-09-15

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