The additive effect of antimicrobial photodynamic therapy for peri-implant disease

JRCT ID: jRCTs072200118

Registered date:31/03/2021

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Peri-implantitis
• Date of first enrollment: 06/05/2021
• Target sample size: 94
• Study type: Interventional

Intervention(s)

*control group: After mechanical debridement and air-abrasion, the peri-implant pocket is irrigated with normal saline on surgical date, 10 (6-14) days after the treatment, and 2 times with an interval of 7 (5-9) days.
*a-PTD group: After mechanical debridement and air-abrasion, the peri-implant pocket is given photodynamic therapy with FotoSan630 using FotoSanAgent as photosensitizer on surgical date, 10 (6-14) days after the treatment, and 2 times with an interval of 7 (5-9) days.

Outcome(s)

• Primary Outcome: Changes in pus discharge volume at day 7.

Secondary Outcome

*Pus discharge volume at month 12
*Inflammation symptoms at day 7
*Pocket depth at month 12
*Alveolar bone height at month 12
*Safety.

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 90age old
• Gender: Both
• Include criteria: Patients with peri-implantitis
• Exclude criteria: Patients with problem in judgement

Related Information

• Primary Sponsor: Ohba Seigo