Prevention of postoperative pneumonia by antimicrobial pharmacy administration in intubated patients after oral surgery: a preliminary study

JRCT ID: jRCTs071230007

Registered date:14/04/2023

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Intubated patients after oral surgery
• Date of first enrollment: 15/05/2023
• Target sample size: 10
• Study type: Interventional
• Intervention(s): One application of tetracycline hydrochloride ointment on the back of the tongue.

Outcome(s)

• Primary Outcome: Bacterial counts in oropharyngeal fluid and retained fluid on the cuff before administration and 1, 2, 3, and 6 hours after administration

Secondary Outcome

1. Antimicrobial drug concentrations in oropharyngeal fluid and supra-cuff fluid before administration and 1, 2, 3, and 6 hours after administration
2. Development of postoperative pneumonia
3. Safety of antimicrobial pharmacy administration

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Oral surgery patients who are managed under intubation by postoperative tracheotomy at Nagasaki University Hospital Oral Surgery or Hiroshima University Hospital Oral and Maxillofacial Surgery between the date of jRCT publication and December 28, 2023.
2. Patients who can personally provide written consent at their own free will after being receiving a thorough explanation of the study and fully understanding their participation in the study.

Exclude criteria

Any of the following patients will be excluded:
1. Patients with past history of allergy for the tetracycline hydrochloride and ampicillin sodium sulbactam sodium
2. Partients who are judged to be inappropriate to participate the study by the principal or cooperative doctors.

Related Information

• Primary Sponsor: Miura Kei-ichiro