Establishment of treatments to improve the endometrial microbiome

JRCT ID: jRCTs071220077

Registered date:06/12/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: infertility
• Date of first enrollment: 31/05/2023
• Target sample size: 150
• Study type: Interventional
• Intervention(s): Vaginal probiotics for endometrial dysbiosis

Outcome(s)

• Primary Outcome: Effectiveness
• Secondary Outcome: Changes in the composition of Lactobacillus species in the endometrial microbiome.

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 39age old
• Gender: Female

Include criteria

1. Patients undergoing IVF and embryo transfer at our OB/GYN department.
2. Patient who have good frozen embryos by egg retrieval surgery.
3. Patient scheduled for a single embryo transfer.

Exclude criteria

1. Patients with a diagnosis of chronic endometritis made by endometrial pathology.
2. Patients with ovarian Insufficiency.
3. Patients with endometrial polyps on hysteroscopy.

Related Information

• Primary Sponsor: Mekaru Keiko
• Source(s) of Monetary Support: Sante Laboratories, Inc,Varinos Inc.