Investigation of the preventive effects of antimicrobial penetrated collargen plug(TERUPLUG) for post-extraction tooth socket for osteonecrosis of the jaw after tooth extraction in patients using high-dose antiresorptive agent

JRCT ID: jRCTs071200006

Registered date:20/04/2020

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Patients receiving high-dose antiresorptive agent
• Date of first enrollment: 02/07/2020
• Target sample size: 30
• Study type: Interventional

Intervention(s)

Intervention group: Insert of antimicrobial(MINOCYCLINE) penetrated collargen plug(TERUPLUG) for post-extraction tooth socket, close the wound, and remove sutures 1 week later.
Control group: Insert of collargen plug(TERUPLUG) for post-extraction tooth socket, close the wound, and remove sutures 1 week later.

Outcome(s)

• Primary Outcome: Incidence of MRONJ 2 months later after tooth extraction
• Secondary Outcome: Association of investigation factors and onset of MRONJ

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Patients receiving ZOMETA or RANMARK therapy who are planned to undergo tooth extraction
• Exclude criteria: Patients with problem in judgement

Related Information

• Primary Sponsor: Soutome Sakiko