AM-AF study

JRCT ID: jRCTs071190005

Registered date:26/04/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: atrial fibrillation
• Date of first enrollment: 08/10/2019
• Target sample size: 16
• Study type: Interventional

Intervention(s)

adrenomedullin arm: adrenomedullin continuous venous infusion (10 ng/kg/min, 8 hours per day) given from the day before catheter ablation to after three days of ablation (total 5 days)
control arm: catheter ablation only

Outcome(s)

• Primary Outcome: Total time of significant atrial arrhythmias within 3 days after catheter ablation

Secondary Outcome

1. rate of atrial arrhythmias within 3 days after catheter ablation
2. rate of atrial arrhythmias from 4 to 14 days after catheter ablation
3. inflammatory makers
4. adverse event

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: patient receiving catheter ablation for persistent atrial fibrillation

Exclude criteria

1. paroxysmal atrial fibrillation
2. significant valvular disease
3. significant heart disease (heart failure, myocardial infarction, angina etc.)
4. hyperthyroidism
5. diameter of left atria over 50 mm
6. active infection or inflammatory disease
7. malignancy

Related Information

• Primary Sponsor: Kitamura Kazuo
• Source(s) of Monetary Support: University of Miyazaki Hospital
• Secondary ID(s): UMIN000031865