Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of patients with allergic rhinitis: an early phase 2 study

JRCT ID: jRCTs062180049

Registered date:14/03/2019

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Allergic rhinitis
• Date of first enrollment: 26/02/2018
• Target sample size: 20
• Study type: Interventional
• Intervention(s): A single intranasal irradiation with narrowband UVB (310 nm) irradiation at a dose of 600 mJ/cm2 using phototherapy device equipped with LED (developed by Daiichi Medical).

Outcome(s)

• Primary Outcome: Changes in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33.
• Secondary Outcome: Nasal symptoms and macroscopic findings of nasal mucosa.

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 65age old
• Gender: Both

Include criteria

1) Adult patients aged 20 or above.
2) Patients who were diagnosed as allergic rhinitis.

Exclude criteria

1) Patients with serious complications
2) Patients who was excluded by investigators

Related Information

• Primary Sponsor: Kitamura Yoshiaki
• Secondary ID(s): Nil known