NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
JRCT ID: jRCTs062180049

Registered date:14/03/2019

Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of patients with allergic rhinitis: an early phase 2 study

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiedAllergic rhinitis
Date of first enrollment26/02/2018
Target sample size20
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)A single intranasal irradiation with narrowband UVB (310 nm) irradiation at a dose of 600 mJ/cm2 using phototherapy device equipped with LED (developed by Daiichi Medical).

Outcome(s)

Primary OutcomeChanges in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33.
Secondary OutcomeNasal symptoms and macroscopic findings of nasal mucosa.

Key inclusion & exclusion criteria

Age minimum>= 20age old
Age maximum< 65age old
GenderBoth
Include criteria1) Adult patients aged 20 or above. 2) Patients who were diagnosed as allergic rhinitis.
Exclude criteria1) Patients with serious complications 2) Patients who was excluded by investigators

Related Information

Contact

Public contact
Name Yoshiaki Kitamura
Address 3-18-15 Kuramoto, Tokushima 770-8503, Japan Tokushima Japan 770-8503
Telephone +81-88-633-7169
E-mail ykitamura@tokushima-u.ac.jp
Affiliation Tokushima University
Scientific contact
Name Yoshiaki Kitamura
Address 3-18-15 Kuramoto, Tokushima 770-8503, Japan Tokushima Japan 770-8503
Telephone +81-88-633-7169
E-mail ykitamura@tokushima-u.ac.jp
Affiliation Tokushima University