Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of healthy subjects: a phase 1 study

JRCT ID: jRCTs062180048

Registered date:14/03/2019

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: non
• Date of first enrollment: 14/09/2017
• Target sample size: 20
• Study type: Interventional
• Intervention(s): A single intranasal irradiation with narrowband UVB (310nm) irradiation at a dose of 600mJ/cm2 using phototherapy devise equipped with LED (developed by Daiichi Medical)

Outcome(s)

• Primary Outcome: Nasal symptoms and macroscopic findings of nasal mucosa
• Secondary Outcome: Changes in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 65age old
• Gender: Both

Include criteria

1) Adult subjects aged 20 or above
2) Healthy subjects without allergic rhinitis and taking any anti-allergic medications

Exclude criteria

1) Subjects with serious complications
2) Subjects who was excluded by investigators

Related Information

• Primary Sponsor: Kitamura Yoshiaki
• Secondary ID(s): Nil known