NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
JRCT ID: jRCTs062180048

Registered date:14/03/2019

Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of healthy subjects: a phase 1 study

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiednon
Date of first enrollment14/09/2017
Target sample size20
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)A single intranasal irradiation with narrowband UVB (310nm) irradiation at a dose of 600mJ/cm2 using phototherapy devise equipped with LED (developed by Daiichi Medical)

Outcome(s)

Primary OutcomeNasal symptoms and macroscopic findings of nasal mucosa
Secondary OutcomeChanges in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33

Key inclusion & exclusion criteria

Age minimum>= 20age old
Age maximum< 65age old
GenderBoth
Include criteria1) Adult subjects aged 20 or above 2) Healthy subjects without allergic rhinitis and taking any anti-allergic medications
Exclude criteria1) Subjects with serious complications 2) Subjects who was excluded by investigators

Related Information

Contact

Public contact
Name Yoshiaki Kitamura
Address 3-18-15 Kuramoto, Tokushima 770-8503, Japan Tokushima Japan 770-8503
Telephone +81-88-633-7169
E-mail ykitamura@tokushima-u.ac.jp
Affiliation Tokushima University
Scientific contact
Name Yoshiaki Kitamura
Address 3-18-15 Kuramoto, Tokushima 770-8503, Japan Tokushima Japan 770-8503
Telephone +81-88-633-7169
E-mail ykitamura@tokushima-u.ac.jp
Affiliation Tokushima University