Evaluation of tissue stiffness in central nervous system tumors using Brain MR elastography

JRCT ID: jRCTs052230155

Registered date:25/12/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Brain tumor
• Date of first enrollment: 04/03/2024
• Target sample size: 50
• Study type: Observational
• Intervention(s): non

Outcome(s)

• Primary Outcome: Correlation between stiffness assessed by MRE and tumor hardness assessed by neurosurgeon

Secondary Outcome

1)Mean value of stiffness by histopathological type evaluated by MRE and its 95% confidence interval
2)Change in stiffness values before and after embolization in patients with meningiomas

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: < 90age old
• Gender: Both

Include criteria

(1) Scheduled surgery at Shiga University of Medical Science Hospital with suspected brain tumor lesion
(2) Aged 18 to 90 at the time of obtaining consent
(3) Written informed consent has been obtained from the patient for participation in this study

Exclude criteria

(1) With a cardiac pacemaker
(2) With cochlear or middle ear implants
(3) Undergone stent insertion surgery within 2 weeks from the scheduled date of MRI examination
(4) Undergone artificial heart valve surgery that is not compatible with MRI
(5) Having (or are suspected to have) fine metal particles in their eyes.
(6) With cerebral aneurysm clips other than titanium
(7) With metal prostheses
(8) Still bolted due to fractures
(9)Having tattoos all over their trunk
(10) With a history of central nervous system disease other than brain tumor scheduled for surgery
(11) Subject with pregnant
(12) Judged by the principal investigator or co-investigator to be inappropriate for the safe conduct of this study

Related Information

• Primary Sponsor: Watanabe Yoshiyuki