Elucidation of epilepsy pathology with intracranial electrode placement

JRCT ID: jRCTs052180096

Registered date:06/03/2019

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Epilepsy
• Date of first enrollment: 24/02/2017
• Target sample size: 25
• Study type: Interventional
• Intervention(s): MRI acquisition in patients with intracranial electrodes implantation

Outcome(s)

• Primary Outcome: Elucidation of disease condition and improvement of surgical treatment outcome in intractable partial epilepsy cases
• Secondary Outcome: Identify epileptic focal points that could not be identified by conventional methods and enable focal resection

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Patients who were diagnosed as refractory epilepsy and regarded as candidates of intracranial electrode recording.
2. Understanding the explanation and confirming the consent of the principal (In the case of an underage, you can also confirm the consent of the adult's substitute other than the principal)
3. MRI imaging required for analysis can be performed stably before and after surgery

Exclude criteria

1.Patients with uncontrolled respiratory and cardiovascular disease
2.Patients with compromised nature
3.Patients with cognitive dysfunction difficult to understand explanations and instructions
4.Patient who is mentally considered to be resistant to intracranial electrode implantation
5.Patients who are considered to be as dangerous as seizure type is an overkinetic seizure and it is impossible to ensure rest during electrode embedding
6.Patients wearing cardiac pacemakers
7.Patients who have metals (aneurysm clips, mechanical artificial valves, nerve stimulation devices, insulin pumps, intraocular metals, etc.) that can not be confirmed as being nonmagnetic

Related Information

• Primary Sponsor: Kikuchi Takayuki
• Secondary Sponsor: Yamao Yukihiro