Clinical Effects of Highly Absorptive Curcumin (curcurouge) on knee osteoarthritis

JRCT ID: jRCTs051230130

Registered date:17/11/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: knee osteoarthritis
• Date of first enrollment: 30/11/2023
• Target sample size: 100
• Study type: Interventional

Intervention(s)

Highly Absorptive Curcumin (curcurouge) on knee o
steoarthritis for three months

Outcome(s)

Primary Outcome

JKOM, VAS, JOA knee OA score, KOOS Japanese version,dependence of N
SAIDs

Secondary Outcome

Time up and go, knee range of motion biochemic
al analysis of blood, responder rate of OMERACT-OARSI

Key inclusion & exclusion criteria

• Age minimum: >= 40age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Medial knee osteoarthritis and KL classification
I or II or III, 2) over 40 years. 3) VAS before starting is more than 30/100, 4) consent of patient , 5)
outpatient

Exclude criteria

1)the patients who take more than 2 kinds of anti-coagulant drugs 2)Severe renal dysfunction or dialysis 3)severe liver dysfunction or liver cirrhosis 4)severe cardiovas
cular diseases 5)severe cerebrovascular dysfuncti
on 6)severe diabetes mellitus 7)curcumin abuse
patients 8)previous knee surgery or intraarticular i
njection for experimental period or steroid intraart
icular injection before 2 months or steroid oral int
ake before 4 weeks 9)patient who must be exclud
ed by the scientific responsible doctor

Related Information

• Primary Sponsor: Nakagawa Yasuaki
• Secondary Sponsor: Therabiopharma Inc.