Novel gastrointestinal-mediated mechanism of action of metformin

JRCT ID: jRCTs051200115

Registered date:19/01/2021

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Patients with type 2 diabetes
• Date of first enrollment: 08/03/2021
• Target sample size: 5
• Study type: Interventional
• Intervention(s): magnetic resonance enterography

Outcome(s)

• Primary Outcome: FDG excretion per hour into the intestinal lumen

Secondary Outcome

HbA1c, plasma glucose levels and various clinical parameters
Presence or absence of disease

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1.Patients with type 2 diabetes
2.Patients taking more than 1000 mg of metformin hydrochloride per day
3.Patients with no obvious lesions in the lower gastrointestinal tract
4.Patients who were 20 years of age or older and Under 75 years old at the time of obtaining consent
5.Patients who have given their voluntary written consent to participate in this clinical study

Exclude criteria

1.Patients with contraindications to scopolamine butylbromide
2.Patients suffering from dementia or mental illness
3.Patients with possible bowel perforation or obstruction
4.Patients with metals in the body that are not amenable to PET/MRE testing
5.Pregnant or breast feeding patients
6.Other patients who are deemed inappropriate by the investigators of this clinical study

Related Information

• Primary Sponsor: Sakaguchi Kazuhiko