Study of the Tolerability of Desflurane Anesthesia Using Intraoperative Motor Evoked Potential Monitoring during Spinal Surgery

JRCT ID: jRCTs041220127

Registered date:26/01/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: all spinal surgery cases
• Date of first enrollment: 21/02/2023
• Target sample size: 62
• Study type: Interventional
• Intervention(s): Propofol and desflurane will be switched during the surgery.

Outcome(s)

• Primary Outcome: The percentage of cases in which MEPs in trapezius muscle in cervical spine cases, deltoid muscle in thoracolumbar spine, and abductor digiti minimi muscle in thoracolumbar spine did not decrease by 70% or more in the control MEP amplitude and the operation was started under desflurane anesthesia and the operation was completed
• Secondary Outcome: Anesthesia-related items such as differences in MEP derivation, amplitude, and latency for each muscle, induction time, time from the end of surgery to extubation, and drug costs from the end of surgery to discharge

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

All spine surgery cases over 18 years old
Understand the research and obtain written consent

Exclude criteria

Age < 18 yr
Scoliosis, intramedullary tumors, ossification of the posterior longitudinal ligament
Cases in which continuation of the study is considered difficult at the discretion of the primary department or anesthesiologist
Patients considered unfit to participate in this study by the investigator or subinvestigator

Related Information

• Primary Sponsor: Tamura Takahiro