Involvement of adenosine receptors with inhalation anesthetics

JRCT ID: jRCTs041190124

Registered date:06/03/2020

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Healthy adult
• Date of first enrollment: 21/01/2021
• Target sample size: 20
• Study type: Interventional
• Intervention(s): Observe and evaluate hypnotic status and recovery process with sevoflurane alone, ATP alone, and sevoflurane and ATP combination

Outcome(s)

• Primary Outcome: Depth of anesthesia (BIS)
• Secondary Outcome: Directed behavior, cognitive ability, psychomotor function, balanced motor function, circulation (heart rate, blood pressure, electrocardiogram), breathing (respiration rate, tidal volume, end-tidal carbon dioxide concentration, SpO2), and safety

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 39age old
• Gender: Male

Include criteria

1. Healthy adult men aged 20 to 39
2. Consent for study participation was obtained by signing consent form for this study

Exclude criteria

1. Person who may cause airway obstruction (e.g.: obesity, sleep apnea syndrome)
2. Person who have previously used a halogenated anesthetic and have jaundice or an unexplained fever
3. Person with a history of hypersensitivity to sevoflurane
4. Person taking psychotropic drugs (including taking sleeping pills)
5. Person with serious liver disorder, kidney disorder, respiratory disease, heart disease
6. Person who is judged unqualified by the study responsible dentist or the study dentist

Related Information

• Primary Sponsor: Sakurai Satoru