Verification of safety and efficacy of nobiletin containing food in cognitive function

JRCT ID: jRCTs041190073

Registered date:11/10/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: subarachnoid hemorrhage, cerebral infarction, cerebral hemorrhage, cerebral contusion injury Head tr
• Date of first enrollment: 21/10/2019
• Target sample size: 122
• Study type: Interventional
• Intervention(s): To evaluate cognitive function improvement effect of combined formulation of nobiletin high purity powder, black turmeric rhizome dry powder and long-lived grass dry powder for forgetful and dementia preliminary forces

Outcome(s)

• Primary Outcome: The Japanese version of the Wechsler memory scale-revised
• Secondary Outcome: Mini Mental State Examination-Japanese, Symbol Digit Modalities Test,Benton Visual Retention Test, Trail Making Test, The General Health Questionnaire, Quality of Life Questionnaire survey, Physical examination, Hematology test, Urine test

Key inclusion & exclusion criteria

• Age minimum: >= 65age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) 1) Men and women over the age of 65 who are aware of forgetfulness.
2) The subjects who displayed 24 scores or more of MMSE.

Exclude criteria

1) The subjects who are likely to have allergy symptoms due to test ingredients
2) The subjects who were diagnosed as patients with dementia
3) The subjects who received surgical operation for stroke, subarachnoid hemorrhage, cerebral infarction, cerebral hemorrhage, cerebral contusion injury Head trauma Those with the inpatient surgery.
4) The subjects with medical history of epilepsy or diabetes and/or receiving medical treatment presently.
5) The subjects who is taking medicines (antipsychotic drugs, anxiolytics, antidepressants, antiparkinsonian drugs, antidepressants, antiepileptic drugs

Related Information

• Primary Sponsor: Ono Ken
• Source(s) of Monetary Support: Okinawa Research Center co.Ltd.