Implementation of first-trimester screening and prevention of preeclampsia

JRCT ID: jRCTs041190035

Registered date:30/05/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: High-risk pregnancy for preterm-preeclampsia identified by screening at 11-13 weeks
• Date of first enrollment: 02/09/2019
• Target sample size: 7800
• Countries of recruitment: Hong Kong,Japan,China,Japan,Taiwan,Japan,Thailand,Japan,Singapore,Japan,Philippines,Japan,Vietnam,Japan
• Study type: Interventional
• Intervention(s): Low-dose aspirin is prescribed every night from before 15 weeks to 36 weeks of gestation to prevent PE in a woman who is at the age of 18 and older, who was screened for PE in an intervention period, and who was identified as a PE high-risk woman.

Outcome(s)

• Primary Outcome: Delivery with preeclampsia at < 37 weeks of gestation
• Secondary Outcome: Abnormal pregnancy outcome (preeclampsia, gestational hypertension, low birth weight infant (SGA; less than 5th percentile of birth weight), stillbirth, placental abruption) at less than 34 weeks of gestation, 34 to 37 weeks of gestation, 37 weeks of gestation or later

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Female
• Include criteria: Singleton pregnancy
• Exclude criteria: Multiple pregnancy, Major fetal defects identified at 11-13 weeks of assessment, Non-viable fetus

Related Information

• Primary Sponsor: Shiozaki Arihiro