NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
JRCT ID: jRCTs041190010

Registered date:10/04/2019

The usefulness of kestose for ulcerative colitis

Basic Information

Recruitment status Complete
Health condition(s) or Problem(s) studiedUlcerative colitis
Date of first enrollment06/04/2018
Target sample size40
Countries of recruitment
Study typeInterventional
Intervention(s)arm A Kestose(10g) every day 8 weeksar arm B Maltose(5g) every day 8 weeks

Outcome(s)

Primary OutcomeImprovement of clinical condition in patients with ulcerative colitis
Secondary Outcome1.Changes of short-chain fatty acid (Butyric acid,Acetic acid,Propionic acid etc.) 2.changes of endoscopic score 3.changes of concentration of carprotectin in feces 4.Changes of pathologic and metabolic marker (T.Cho, LDL-Cho, HDL-Cho, TG, FFA, ferritin,HbA1c,CRP,TP,ALB etc.) 5.Correlation of gut microbiota and therapeutic effect 6.Changes of body weight and BMI 7.Metabolome and protein analysis of metabolite in feces 8.Changes of bile acid 9.Correlation between expiratory noble gases, gut microbiota and ulcerative colitis 10.Correlation between usefulness of kestose and disease prognosis in the patients with ulcerative colitis

Key inclusion & exclusion criteria

Age minimum>= 20age old
Age maximum<= 80age old
GenderBoth
Include criteriaPatients with active ulcerative colitis (Lichtiger CAI>3)
Exclude criteria1.Women with pregnancy or possible pregnancy 2.Patients with severe renal failure and heart failure 3.Patient who is considered to be inappropriate for entry into the trial by the investigator 4.Medical doctors decided the patients are inappropriate.

Related Information

Contact

Public contact
Name Syuuji Ikegami
Address 65 Tsurumai-cho Syowa-ku Nagoya, Japan Aichi Japan 466-8560
Telephone +81-52-744-2169
E-mail s.ikegami@med.nagoya-u.ac.jp
Affiliation Nagoya university
Scientific contact
Name Takashi Honda
Address 65 Tsurumai-cho Syowa-ku Nagoya, Japan Aichi Japan 466-8560
Telephone +81-52-741-2111
E-mail honda@med.nagoya-u.ac.jp
Affiliation Nagoya university