The efficacy of elobixibat as bowel cleansing agent for bowel preparation before colonoscopy

JRCT ID: jRCTs041180026

Registered date:16/01/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: require colonoscopy
• Date of first enrollment: 07/01/2018
• Target sample size: 154
• Study type: Interventional
• Intervention(s): oral administration of elobixibat

Outcome(s)

• Primary Outcome: Colonoscopy preparation time, The quality of bowel preparation

Secondary Outcome

Patient background
Underlying disease
Adverse events in preparation
Preparation addition
Endoscope insertion time
Endoscope observation time
Endoscope insertion rate
ADR (Adenoma detection rate)
Patient acceptability
Satisfaction level

Key inclusion & exclusion criteria

• Age minimum: 20age
• Age maximum: none
• Gender: Both
• Include criteria: adults at least 20 years of age
• Exclude criteria: If they had any of the following conditions: ileus, suspected bowel obstruction or toxic megacolon; prior abdominal or pelvic surgery; inflammatory bowel disease; malignancy; severe cardiac disease (heart failure beyond NYHA Class III); chronic obstructive pulmonary disease, interstitial lung disease or uncontrolled asthma; renal failure and on dialysis, decompensated liver cirrhosis; coagulopathy or other hematologic disease with bleeding tendency; dementia or other cognitive disorders; or hypersensitivity to elobixibat. And if they were pregnant or breastfeeding.

Related Information

• Primary Sponsor: Yamaguchi Daisuke