Influence of daily or alternate-day dosing of vonoprazan on intragastric pH, serum gastrin and anti platelet function of clopidogrel

JRCT ID: jRCTs041180024

Registered date:28/12/2018

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: N/A
• Date of first enrollment: 21/02/2019
• Target sample size: 20
• Study type: Interventional

Intervention(s)

Regimen1:VPZ(10mg) every other day + CLP(75mg) every day after breakfast
Regimen2:VPZ(10mg) every day + CLP(75mg) every day after breakfast
Regimen3:CLP(75mg) every day after breakfast

Outcome(s)

• Primary Outcome: pH4 HTR: pH holding time ratio
• Secondary Outcome: Serum gastrin level and IPA

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1.Healthy adults over 20 years old.
2.For this research, those who obtained consent by signing the consent form by himself / herself.
3.Persons who are negative for anti-H. pylori IgG antibody, have not used the drugs in the past month.

Exclude criteria

1.Persons who have a history of heart disease.
2.Persons with severe liver disease(AST:over 100 U/L).
3.Persons with severe kidney disease(Serum creatinine:over 1.3 mg/dl).
4.Women who are pregnant or may become pregnant.
5.A lactating women.
6.Those with upper gastrointestinal disorder, or those with a history.
7.H. pylori positive persons.
8.Those using drugs.
9.Smokers.
10.Those judged unsuitable by researcher or responsible responsibility sharing doctor.

Related Information

• Primary Sponsor: Furuta Takahisa