Efficacy of a 3-Day Doxycycline Course in Chlamydia trachomatis Treatment

JRCT ID: jRCTs031240353

Registered date:26/09/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Chlamydia infection
• Date of first enrollment: 17/10/2024
• Target sample size: 160
• Study type: Interventional
• Intervention(s): Doxycycline 100 mg administered orally twice daily for three days.

Outcome(s)

Primary Outcome

Treatment success rate at 28 days post-treatment (all sites)
The treatment success is defined by a negative result on a nucleic acid amplification test after treatment.
In cases of multiple site infections, the treatment is considered a failure if even one site remains positive.
For each specific site, treatment success is confirmed by a negative result at the corresponding site.

Secondary Outcome

Treatment success rate at 28 days post-treatment (by site)
Treatment success rate at 14 days post-treatment (all sites, by site)
Symptom resolution rate: the proportion of symptomatic individuals who experience symptom relief
Incidence rate of adverse events

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Adults aged 18 years or older at the time of consent acquisition.
2. Individuals in whom Chlamydia trachomatis has been detected in urine, pharyngeal, vaginal, or rectal specimens.
3. Individuals who have provided written consent to participate in the study.

Exclude criteria

1. Individuals who are allergic to the treatment medication.
2. Individuals who are pregnant or breastfeeding.
3. Individuals whom the attending physician deems unsuitable for participation in the study.

Related Information

• Primary Sponsor: Ando Naokatsu