Effect of Astragalus Root on CKD

JRCT ID: jRCTs031210058

Registered date:27/04/2021

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Chronic kidney disease
• Date of first enrollment: 15/06/2021
• Target sample size: 160
• Study type: Interventional
• Intervention(s): Astragalus Root powder (0.07g/kg/day) given orally 2 times daily from 3 months to 15 months after registration

Outcome(s)

• Primary Outcome: slope of eGFR

Secondary Outcome

1. eGFR
2. SCr
3. BUN
4. Protein-to-creatinine ratios (Up/Cr)

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Chronic kidney disease (CKD)
2) eGFR: 15-60mL/min/1.73m2 (stage3 or 4)
3) Age: = or >20 years old
4) Male and female
5) Outpatient of Kampo medicine clinic or general medicine clinic at Tokai university hospital, or clinic of Shonan hospital
6) No major changes in medication
7) Written informed consent

Exclude criteria

1) Improper dosing
2) Allergies to Kampo medicine
3) Pregnant

Related Information

• Primary Sponsor: Oki Masayuki
• Source(s) of Monetary Support: The Japan Society for the Promotion of Science