In vivo quantification of central phosphodiesterase 7

JRCT ID: jRCTs031190054

Registered date:12/07/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Health Condition
• Date of first enrollment: 01/08/2019
• Target sample size: 12
• Study type: Interventional
• Intervention(s): Injection of [11C]MTP38

Outcome(s)

• Primary Outcome: Pharmacokinetics, and distribution volume or binding potentials of [11C]MTP38 in human brain
• Secondary Outcome: Association between distribution volume of [11C]MTP38 and MRI data

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 50age old
• Gender: Male
• Include criteria: Healthy male subjects

Exclude criteria

1.Subjects who do not have ability to make informed consent.
2. Subjects with any psychiatric disorder or subjects with severe physical complication.
3. Subjects who currently smokes.
4. Subjects with any organic brain disorder.
5. Subjects with metallic medical device in the body.
6. Subjects with tattoo.
7. Subjects with severe claustrophobia.
8. Subjects with a history of allergy to heparin and local anesthetics.
9. Subjects who are taking an anticoagulant.
10. Subjects who has participated in other study in recent 6 months.
11. Subjects who has participated in blood donation in recent 12 weeks.
12. Subjects who is considered to be inappropriate to participate in the study.

Related Information

• Primary Sponsor: Tagai Kenji