Randomized controlled trial of desflurane vs. sevoflurane in pediatric liver transplant patients (liver des-sev)

JRCT ID: jRCTs031180416

Registered date:22/03/2019

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Pediatric patients who are scheduled for living donor liver transplantation
• Date of first enrollment: 22/06/2016
• Target sample size: 65
• Study type: Interventional

Intervention(s)

Arm S: anesthesia by sevoflurane
Arm D: anesthesia by desflurane

Outcome(s)

• Primary Outcome: Ratio of operating room extubation after pediatric living donor liver transplantation

Secondary Outcome

1) Length of postoperative intubation
2) Length of Intensive care unit stay
3) Perioperative blood examination
4) Perioperative vital sign change
5) Perioperative infusion therapy volume
6) Perioperative urine output change
7) Ratio of postoperative infection
8) Ratio of postoperative rejection

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: < 16age old
• Gender: Both
• Include criteria: 1) patients who are scheduled for living donor liver transplantation at National Center for Child Health and Development, Tokyo, Japan; 2) patients weighted more than or equal to 6kg; 3) patients aged less than 16 years old; 4) patients whose informed consent is obtained from their guardians before operation
• Exclude criteria: 1) preoperative ICU management; 2) other organ complications caused by diseases other than the present liver illness; 3) allergy to either/both of inhalation anesthetic(s) or halogenated agents; 4) past history of malignant hyperthermia or family history of malignant hyperthermia; 5) metabolic disease; 6) acute liver failure; 7) pulmonary hypertension; 8) respiratory tract symptoms within 2 weeks before surgery; 9) asthma; 10) any cases inappropriate for the trial judged by surgeons or anesthesiologists in charge

Related Information

• Primary Sponsor: Yukimasa Sho
• Secondary ID(s): UMIN000022811