In vivo quantification of the cerebral monoacylglycerol lipase using [18F]T-401

JRCT ID: jRCTs031180045

Registered date:29/11/2018

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Healthy subjects, Alzheimer's disease, NSMOD, PSP
• Date of first enrollment: 03/04/2018
• Target sample size: 23
• Study type: Interventional
• Intervention(s): Injection of [18F]T401 and PET scan

Outcome(s)

Primary Outcome

Pharmacokinetics and distribution volume of[18F]T-401 in human brain.
Effective dose of [18F]T-401 in human

• Secondary Outcome: Relationship among the density of MAGL, feeding and cognitive function

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Healthy male subjects and patients with Alzheimer's disease, NSMOD and PSP

Exclude criteria

1.Subjects who do not have ability to make informed consent.
2. Subjects with any psychiatric disorder or subjects with severe physical complication.
3. Subjects who currently smokes.
4. Subjects with any organic brain disorder.
5. Subjects with metallic medical device in the body.
6. Subjects with tattoo.
7. Subjects with severe claustrophobia.
8. Subjects with a history of allergy to heparin and local anesthetics.
9. Subjects who has participated in other study in recent 6 months.
10. Subjects who has participated in blood donation in recent 12 weeks.
11. Subjects who is considered to be inappropriate to participate in the study.

Related Information

• Primary Sponsor: Takahata Keisuke
• Secondary ID(s): UMIN000031787