Verification of efficacy of root resection using CGF

JRCT ID: jRCTc020190025

Registered date:31/03/2020

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Health probrem studied
• Date of first enrollment: 20/02/2019
• Target sample size: 24
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Root resection will be performed in accordance with the back root canal filling method using MTA cement supervised by the Japan Endodontic Society. CGF is prepared by centrifugation, and divided into a CGF combination group and an unused group by random assignment, and transplanted to the apical periodontal tissue defect.

Outcome(s)

Primary Outcome

1) Statistical analysis items
Preoperative dental cone beam CT and intraoperative bone defect classification
Observation of three-dimensional bone regeneration by dental cone beam CT imaging at 6 months after surgery
Measurement of lesion reduction rate
Take dental photographs every 3 months up to 12 months and measure the reduction rate of lesions
The above data will be used to compare the effectiveness of bone regeneration between the two groups with and without CGF using statistical methods such as Mann-Whitney's U test or Student t-test.
2) Determination of clinical symptoms
Immediately before and after surgery, determine the degree of pain, percussion pain, and apical tenderness during the follow-up period

• Secondary Outcome: none

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 70age old
• Gender: Both

Include criteria

1.Root resection is considered an effective means for resolving the patient's chief complaint and hopes
2. Patients with good general condition
3. Patients with a platelet count of 100,000 / mm3 or more
4. Patients aged 20 to 70
5. Consent for participation in research should be obtained in writing

Exclude criteria

1. Patients who have or have a history of malignancy
2. Patients with abnormal gingival growth or history
3. Malignant tumors, precancerous lesions or suspicious findings are observed in the oral cavity diagnosis
4. Patients under 20 or over 70
5. Other patients who are judged inappropriate by dentists who provide regenerative medicine etc.

Related Information

• Primary Sponsor: Saito Masahiro
• Source(s) of Monetary Support: Japanese Association for Dental Science