Ivosidenib in participants with locally advanced or metastatic conventional chondrosarcoma untreated or previously treated with 1 systemic treatment regimen

JRCT ID: jRCT2061240032

Registered date:12/07/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, 0 or 1 Regimen
• Date of first enrollment: 28/06/2024
• Target sample size: 136
• Countries of recruitment: Australia,Japan,United States,Japan,Canada,Japan,Brazil,Japan,Belgium,Japan,France,Japan,Germany,Japan,Netherland,Japan,Italy,Japan,Spain,Japan,United Kingdom,Japan
• Study type: Interventional

Intervention(s)

Drug: Ivosidenib 500mg or Placebo
Provided as tablets, taken orally as two 250mg tablets/Placebo once daily.

Outcome(s)

• Primary Outcome: Progression-free survival (PFS) based on Blinded Independent Central Reviewer (BICR) assessment in Grade 1 and Grade 2 participants
• Secondary Outcome: PFS based on BICR assessment in all randomized participants

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

Have a histopathological diagnosis (fresh or banked tumor biopsy sample collected within the last 3 years) consistent with locally advanced or metastatic conventional chondrosarcoma Grades 1, 2, or 3 and not eligible for curative resection.
Have at least one BICR confirmed measurable lesion as defined by RECIST v1.1. Participants who have received prior radiation therapy are eligible provided measurable disease falls outside of the treatment field or within the field and has shown more than 20% growth in size since post treatment assessment.
Have received 0 or 1 prior systemic treatment regimen in the advanced/metastatic setting for chondrosarcoma.
Have radiographic progression/recurrence of disease according to RECIST v1.1 defined as
Radiographic progression of disease (local and/or distant) documented by 2 imaging assessments performed no more than 6 months apart within 12 months before randomization.
OR
Any recurrence of disease (local and/or distant) after complete surgical resection and documented by imaging within 6 months before randomization.
Have documented IDH1 gene mutated disease (from a fresh tumor biopsy or the most recent banked tumor tissue available that was sourced from either a primary or metastatic tumor lesion) based on central laboratory testing (R132C,L,G,H,S mutation variants tested)
Have recovered from any clinically relevant sequelae and toxic effects of any prior surgery, radiotherapy, or other therapy intended for the treatment of cancer.

Exclude criteria

Are unable to swallow oral medication.
Pregnant or lactating women.
Are participating in another interventional study at the same time; participation in noninterventional registries or epidemiological studies is allowed.
Have received prior therapy with an IDH1 inhibitor
Have received systemic anticancer therapy within 2 weeks prior to randomization (for investigational or immune-based anticancer therapy within 4 weeks).
Have received radiotherapy within 2 weeks prior to randomization.
Have known symptomatic brain metastases requiring steroids more than10 mg per day prednisone (or equivalent). Participants with previously diagnosed brain metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued or reduced corticosteroid treatment less than 10 mg per day for these metastases for at least 4 weeks and have radiographically stable disease of brain lesions for at least 3 months prior to randomization.
Have a history of another primary cancer, with the exception of: a) curatively resected non melanoma skin cancer; b) curatively treated carcinoma in situ; or c) pT1-2 prostatic cancer Gleason score <6 or d) participant is free of other primary solid or liquid tumor for more than 1 year prior to the start of study treatment and, in the opinion of the Investigator, the disease will not affect participant's outcome in the setting of current chondrosarcoma diagnosis.
Have had major surgery within 4 weeks prior to randomization.
Have significant active cardiac disease within 6 months prior to randomization, including New York Heart Association (NYHA) Class III or IV congestive heart failure; myocardial infarction; unstable angina; and/or stroke.
Have LVEF less than 40% by ECHO scan (or by other methods according to institutional practice) obtained within 28 days prior to randomization.
Have a heart-rate corrected QT interval (using Fridericia's formula) (QTcF) more than 450 msec or other factors that increase the risk of QT prolongation or arrhythmic events (eg, heart failure, hypokalemia, family history of long QT interval syndrome). Participants with a bundle branch block combined with a prolonged QTcF interval may be permitted based on local cardiology assessment.
Have known medical history of progressive multifocal leukoencephalopathy (PML).

Related Information

• Primary Sponsor: Debruyne Channa