Phase 3 study to evaluate two regimens of ianalumab on top of standard-of-care therapy in patients with systemic lupus erythematosus (SIRIUS-SLE 1)

JRCT ID: jRCT2061220094

Registered date:09/02/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Systemic lupus erythematosus
• Date of first enrollment: 22/06/2023
• Target sample size: 24
• Countries of recruitment: Spain,Japan,Brazil,Japan,Bulgaria,Japan,Canada,Japan,China,Japan,Czech Republic,Japan,Guatemala,Japan,Hungary,Japan,Israel,Japan,Poland,Japan,Portugal,Japan,Singapore,Japan,Slovakia,Japan,South Africa,Japan,Thailand,Japan,Turkey,Japan,United States,Japan
• Study type: Interventional

Intervention(s)

Arm 1: ianalumab s.c. monthly
Arm 2: ianalumab s.c. quarterly
Arm 3: placebo s.c. monthly

Outcome(s)

• Primary Outcome: Proportion of participants achieving SRI-4 at Week 60

Key inclusion & exclusion criteria

• Age minimum: >= 12age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

- Male and female participants aged 12 years or older at the time of screening, or limited to 18 years or older in European Economic Area countries and other countries where inclusion of participants below 18 years is not allowed.
- Diagnosis of systemic lupus erythematosus according to European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criteria at least 6 months prior to screening
- Elevated serum titers at screening of anti-nuclear antibodies => 1:80 as determined by a central laboratory with a SLE typical fluorescence pattern.
- Currently receiving CS and/or anti-malarial treatment and/or another disease-modifying antirheumatic drug (DMARD) as specified in the protocol.
- SLEDAI-2K criteria at screening: SLEDAI-2K score => 6 points, excluding points attributed to 'fever', 'lupus headache', 'alopecia', and 'organic brain syndrome'
- BILAG-2004 disease activity level at screening of at least 1 of the following:
- BILAG-2004 level 'A' disease in => 1 organ system,
Or
- BILAG-2004 level 'B' disease in => 2 organ systems
- Weigh at least 35 kg at screening

Exclude criteria

- Prior treatment with ianalumab
- History of receiving following treatment I) high dose CS, calcineurin inhibitors, JAK or other kinase inhibitors or other DMARD (except as listed in inclusion criteria) administered within 12 weeks prior to screening II) cyclophosphamide or biologics such as immunoglobulins (i.v. or s.c.), plasmapheresis, anti-type I interferon receptor biologic agents, anti-CD40 agents, CTLA4-Fc Ig or B-cell activating factor (BAFF)-targeting agents administered within 24 weeks prior to screening; belimumab administered within 12 weeks prior to screening. III) any B cell-depleting therapies, other than ianalumab administered within 36 weeks prior to randomization or as long as B cell count is less than the lower limit of normal or baseline value prior to receipt of B cell-depleting therapy (whichever is lower).
-Active viral, bacterial or other infections requiring systemic treatment at the time of screening or randomization or history of recurrent clinically significant infection
- Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV)
- Evidence of active tuberculosis infection
- History of primary or secondary immunodeficiency, including a positive human immunodeficiency virus (HIV) test result at screening
- Any one of the following abnormal laboratory values prior to randomization
- Platelets < 25000/ mm^3 (< 25 x 10^3/ micro L)
- Hemoglobin (Hgb) < 8.0 g/dL (< 5 mmol/L), or < 7.0 g/dL (< 4.3 mmol/L) if related to participant's systemic lupus erythematosus such as in active hemolytic anaemia
- Absolute neutrophil count (ANC) (< 0.8 x 10^3/ micro L)
- Severe organ dysfunction or life-threatening disease at screening
- Presence of severe lupus kidney disease as defined by proteinuria above 2 g/day or equivalent using spot urine protein creatinine ratio
- Receipt of live/attenuated vaccine within a 4-week period before first dosing
- Any uncontrolled, co-existing serious disease, which in the opinion of the investigator will place the participant at risk for participation or interfere with evaluation for SLE-related symptoms
- Non-lupus conditions such as asthma, gout or urticaria, requiring intermittent or chronic treatment with systemic corticosteroid
- History of malignancy of any organ system other than localized basal cell carcinoma of the skin or in situ cervical cancer
- Pregnant or nursing (lactating) women.
- Women of child-bearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception while on study treatment and for 6 months after stopping of investigational drug.
- Any surgical, medical, psychiatric or additional physical condition that may jeopardize participation in this study

Related Information

• Primary Sponsor: Hirano Takamitsu
• Secondary ID(s): NCT05639114