A study to evaluate the efficacy and safety of eneboparatide (AZP-3601) in patients with chronic hypoparathyroidism

JRCT ID: jRCT2051240158

Registered date:10/10/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: chronic hypoparathyroidism
• Date of first enrollment: 18/10/2024
• Target sample size: 12
• Countries of recruitment: USA,Japan,UK,Japan,Spain,Japan,Portugal,Japan,Poland,Japan,Netherlands,Japan,Italy,Japan,Hungary,Japan,Germany,Japan,France,Japan,Denmark,Japan,Canada,Japan,Belgium,Japan
• Study type: Interventional
• Intervention(s): eneboparatide starting dose of 20 micro g/day once daily by SC injection.

Outcome(s)

Primary Outcome

After 24 weeks of treatment, the proportion of patients:
a. Achieving complete independence from active vitamin D; and
b. Achieving independence from therapeutic doses of oral calcium (i.e. taking oral elemental calcium supplements <= 600 mg/day); and
c. With albumin-adjusted serum calcium within the normal range (8.3 to 10.6 mg/dL).

• Secondary Outcome: The proportion of patients who had hypercalciuria at baseline and normalize their 24-hour urinary calcium level (i.e. achieve <250 mg/24 hours for females or <300 mg/24 hours for males)

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: < 80age old
• Gender: Both

Include criteria

1. Males and Females, 18-80 years of age
2. Patients with chronic hypoparathyroidism (cHP) for >=12 months at the time of screening
3. Two paired measurements of showing low parathyroid hormone (PTH) and serum calcium either below normal or within normal under standard of care
4. Requirement for therapy with calcitriol >=0.5 mcg per day or alphacalcidol >=1 mcg per day, and requirement for supplemental oral calcium treatment >=1000 mg per day over and above patient's dietary calcium intake at Day 1 visit
For the Japan cohort, the following patients will be enrolled;
a. Requirement for therapy with calcitriol >=0.5 micro g per day, alfacalcidol >=1 micro g per day, or falecalcitriol >= 0.3 micro g per day, and requirement for supplemental oral (elemental) calcium treatment >=1000 mg per day over and above patient7' dietary calcium intake at Day 1 visit;
OR
b. Requirement for therapy with calcitriol >= 1 micro g per day, alfacalcidol >= 2 micro g per day, or falecalcitriol >= 0.6 micro g per day at Day 1 visit (no minimum daily dose limit for oral calcium supplementation);
5. Successful completion of the Optimization period based on two consecutive measurements of albumin-adjusted serum calcium at least 1 week apart within the range of 7.8 to 9.0 mg/dL and with no more than 25% of change in the daily dose of any of active vitamin D and oral calcium supplements between the two measurements
6. Thyroid-stimulating hormone (TSH) within the lower limit of normal and 1.5-fold of the upper limit of normal at screening; if on suppressive therapy for a history of thyroid cancer, TSH level must be >=0.2 mIU/mL and thyroid medication should be stable for at least 6 weeks prior to treatment
7.Prior to start of treatment:
a. Magnesium level within laboratory normal limits
b. 25(OH) vitamin D levels of 30-70 ng/mL (75-175 nmol/L)
eGFR >=30 mL/min/1.73m2 during screening
8. Able to perform daily subcutaneous self-injections of study drug (or have a designee to perform injections) via a pre-filled injection pen
9. Female patients of non-childbearing potential or using an effective method of contraception throughout the study. Women of childbearing potential should have a negative pregnancy test.
10. Able and willing to provide written and signed informed consent in accordance with GCP

Exclude criteria

1. Mental incapacity, unwillingness, or language barriers precluding adequate understanding or cooperation
2. Clinically significant abnormal values at screening for hematology, clinical chemistry, coagulation or urinalysis
3. Abnormal arterial pressure at screening, defined as (1) systolic blood pressure <100 mmHg, or (2) systolic blood pressure >150 mmHg, and/or diastolic blood pressure >100 mmHg.
4. Heart rate at rest outside the range of 50-100 beats/minute at screening
5. Clinically significant abnormal standard 12-lead electrocardiogram indicative of severe cardiac disease
6. Known history of autosomal-dominant hypocalcemia or known pseudohypoparathyroidism (impaired responsiveness to PTH)
7. Any current disease (other than hypoparathyroidism) that might affect calcium metabolism, calcium-phosphate homeostasis or PTH levels
8. Patients with increased risk for osteosarcoma
9. Current uncontrolled active disease processes that may adversely affect gastrointestinal absorption
10. History of cerebrovascular accident within 6 months prior to screening
11. History of active uncontrolled malignancy over the past 2 years at time of screening
12. History of any other cancer other than thyroid cancer (except basal cell skin cancer or squamous cell skin cancer) who have not been disease-free for a period of at least 2 years at the time of screening
13. Acute gout <2 months prior to screening
14. Dependent on parenteral calcium infusions to maintain calcium homeostasis
15. Use of medications such as loop and thiazide diuretics, raloxifene hydrochloride, lithium, methotrexate, cardiac glycosides or systemic corticosteroids within 4 weeks prior to start of treatment
16. Previous treatment with PTH/parathyroid hormone-related protein-like drugs, including PTH(1-84) and PTH(1-34) within 3 months of screening
17. Use of other drugs known to influence calcium and bone metabolism within 4 weeks of screening
18. Use of oral bisphosphonates within 6 months of screening or intravenous bisphosphonate within 12 months of screening
19. Use of denosumab within 18 months of screening
20. Seizure disorder/epilepsy with history of a seizure within 6 months of screening
21. History of symptomatic urinary tract calculi within 3 months of screening
22. Irradiation to the skeleton within 2 years of screening
23. Pregnant or breastfeeding female patients
24. Participation in any other interventional study in which the patient received an investigational drug or device within 2 months or within 5 times the half-life of the investigational drug (whichever comes first) prior to screening
25. Any disease or condition that, in the opinion of the investigator, may require treatment or make the subject unlikely to fully complete the trial, or any condition that presents undue risk from the study treatment or procedures, including treated malignancies that are likely to recur within the approximate duration of the trial
26. Any other reason that in the opinion of the investigator would prevent the subject from completing participation or following the trial schedule
27. Known allergy or sensitivity to PTH or any of the excipients

Related Information

• Primary Sponsor: Soraya Allas
• Secondary ID(s): NCT05778071