JRCT ID: jRCT1091220045
Registered date:31/08/2010
Effect of high dose inhaled corticosteroid on airway remodeling in asthmatic patients with IL13, STAT4, GLCCI1, CHI3L1, and other SNPs homozygote
Basic Information
Recruitment status | RECRUITING |
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Health condition(s) or Problem(s) studied | Bronchial asthma |
Date of first enrollment | 01/02/2009 |
Target sample size | 100 |
Countries of recruitment | Japan |
Study type | Interventional |
Intervention(s) | Intervention type:DRUG Name of intervention:high-dose inhaled corticosteroid Dose form / Japanese Medical Device Nomenclature:INHALANT Route of administration / Site of application:INHALATIONAL Dose per administration:400 800 microgram Dosing frequency / Frequency of use:BID everyday Planned duration of intervention:260 weeks Intended dose regimen:400 microgram bid detailes of teratment arms: Comparative intervention name:standard treatment Dose form / Japanese Medical Device Nomenclature:INHALANT Route of administration / Site of application:INHALATIONAL Dose per administration:400-800 800-1600 microgram Dosing frequency / Frequency of use:QD everyday Planned duration of intervention:260 weeks Intended dose regimen:usual use |
Outcome(s)
Primary Outcome | pulmonary function |
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Secondary Outcome | Subepithelia layer thickness and concentration of the mediators in bronchial lavage fluid |
Key inclusion & exclusion criteria
Age minimum | >= 18age old |
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Age maximum | Not applicable |
Gender | Both |
Include criteria | Bronchial asthmatic patinets |
Exclude criteria | current smoker |
Related Information
Primary Sponsor | Yutaka Nakamura |
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Secondary Sponsor | Iwate Medical University |
Source(s) of Monetary Support | Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science |
Secondary ID(s) | JMA-IIA00045 |
Contact
Public contact | |
Name | Yutaka Nakamura |
Address | 19-1 Uchimaru, Morioka, |
Telephone | +81-19-651-5111 |
ICB75097@nifty.com | |
Affiliation | Iwate Medical University School of Medicine |
Scientific contact | |
Name | Yutaka Nakamura |
Address | 19-1 Uchimaru, Morioka |
Telephone | +81-19-651-5111 |
Affiliation | Iwate Medical University School of Medicine |