Effect of mechanical stress due to gravity on cytokine changes after aerobic exercise

JRCT ID: jRCT1072230111

Registered date:26/01/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Healthy adults in an environment simulating microgravity
• Date of first enrollment: 03/07/2023
• Target sample size: 16
• Study type: Interventional
• Intervention(s): Perform 30 minutes of normal bicycle pedaling exercise and 30 minutes of bicycle pedaling exercise in the side-lying position, respectively.

Outcome(s)

• Primary Outcome: Changes in myokine before and after exercise

Secondary Outcome

1)Body composition measurement
2)Height and weight measurement
3)Lower limb muscle strength measurement
4)Exhaled breath analysis
5)blood biochemistry test

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 45age old
• Gender: Both

Include criteria

1)Men and women between the ages of 20 and 45 at the time of consent
2)Non-smokers
3)No regular exercise habits within the past 6 months from the time of participation

Exclude criteria

1)People with severe heart failure, renal failure, respiratory failure, cerebrovascular disease, or other malignant diseases
2)People with inflammatory diseases
3)People with physical abnormalities other than those listed above that make exercise difficult
4)Persons who are prohibited from exercising by a physician
5)People who are currently taking medication that affects bone metabolism
6)People who used bone resorption inhibitors such as bisphosphonates or teriparatide until one year ago

Related Information

• Primary Sponsor: Tajima Hiroshi