A study on the extent to which exercise and nutrition intervention improves physical fitness in elderly patients with sarcopenia

JRCT ID: jRCT1072230021

Registered date:16/06/2023

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Elderly patients with sarcopenia
• Date of first enrollment: 16/06/2023
• Target sample size: 40
• Study type: Interventional
• Intervention(s): The intervention group will receive whey protein prior to exercise in an amount equal to 1.0 g protein per body weight daily combined with their regular diet, and will perform HIIT (High Intensity Interval Exercise Training) three times per week. On days when HIIT is not performed, whey protein should be consumed before bedtime. Heart rate during exercise will be monitored with a portable activity monitor.

Outcome(s)

• Primary Outcome: Improving in peak Oxygen consumption
• Secondary Outcome: Improvement of 6-minute walking distance, respiratory function index, walking speed, grip strength, maximum knee extension tension, body composition (lean body mass, abdominal visceral fat mass), echocardiographic index (at rest, during exercise), etc.

Key inclusion & exclusion criteria

• Age minimum: >= 60age old
• Age maximum: <= 75age old
• Gender: Both

Include criteria

Men and women between the ages of 60 and 75
Elderly patients with sarcopenia who are eligible for exercise training intervention
Patients with the written consent

Exclude criteria

Uncontrolled symptomatic heart failure
Symptomatic angina pectoris, or ischemic heart disease
Valvular disease of moderate severity or greater
Bradycardia [pulse rate less than 50 beats per minute] or atrioventricular block of degree 2 or higher
Sustained or persistent atrial fibrillatiom
Renal failure
Systolic blood pressure of 100 mmHg or less
History of asthma or chronic obstructive pulmonary disease
Orthopedic complication [low back pain, knee pain, hip pain that is difficult to treat with exercise therapy]

Related Information

• Primary Sponsor: Hieda Michinari
• Source(s) of Monetary Support: MInistry of Health, Labour, and Welfare