Association of high frequency variable index with hemodynamic changes

JRCT ID: jRCT1072230012

Registered date:29/04/2023

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: patients undergoing general anesthesia
• Date of first enrollment: 29/04/2023
• Target sample size: 20
• Study type: Observational

Outcome(s)

• Primary Outcome: Correlation between HFVI value before tracheal intubation, HFVI variability before and after induction, and mean blood pressure variability before and after tracheal intubation

Secondary Outcome

Variability of Blood Pressure and Heart Rate before and after Anesthesia Induction,
Hypotension during Anesthesia Induction (more than 30% decrease in blood pressure compared to before anesthesia induction),
Hypertension after Tracheal Intubation (more than 30% increase in blood pressure compared to before anesthesia induction),
Time from Administration of Medication to Loss of Consciousness,
Blood Pressure, Heart Rate, and HFVI 5 and 10 minutes after Tracheal Intubation

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

20 patients aged 18 years or older undergoing general anesthesia
The patients have no severe systemic complication (American Society of Anesthesiologists Physical Status-PS 1-2).
The research participant (anesthesiology patient) assigned to the research group is explained about the research during preoperative examination and anesthesia explanation. It is ensured that participation is voluntary.

Exclude criteria

Preoperative disability of central nervous system,
Patients have past history of drug dependence,
Patients with uncontrolled hypertension,
Patients with disability of autonomic nervous system,
Patients with diabetic neuropathy,
Patients with Arrhythmias,
Pregnant woman,
Breast feeding mother,
Patients with Myasthenia gravis
Patients with end-stage renal failure (GFR <15 mL/min/1.73m2) and those undergoing dialysis
Patients with alcohol addiction or alcohol use disorde
Emergent surgial cases

Related Information

• Primary Sponsor: Hirata Naoyuki