The influence of remimazolam on the neuromuscular transmission

JRCT ID: jRCT1071230039

Registered date:12/07/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Patients scheduled for elective surgery under general anesthesia in the supine position
• Date of first enrollment: 24/07/2023
• Target sample size: 15
• Countries of recruitment: noe,Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Changes of TOF ratio and T1 response after conversion of maintenance of anesthesia with propofol to that with remimazolam
• Secondary Outcome: Correlation between the rate of changes of TOF ratio or T1 response and basic demographic data of the patients (age, sex, height, weight, body mass index, liver and renal function), dose of remimazolam and depth of anesthesia

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Patients over 18 years old scheduled for elective surgery under general anesthesia in the supine position without neuromuscular blockade. All patients were American Society of Anesthesiologists physical status class I or II.
• Exclude criteria: Patients under 18 years old, with known or suspected difficult airway and a history of gastroesophageal reflux or increased risk factors for aspiration, with neuromuscular disorder, with contraindication to benzodiazepine

Related Information

• Primary Sponsor: Fujimoto Masafumi