Efficacy of corticosteroid irrigation of the major salivary glands for xerostomia following head and neck cancer radiotherapy

JRCT ID: jRCT1071210017

Registered date:30/04/2021

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: xerostomia
• Date of first enrollment: 31/10/2022
• Target sample size: 40
• Study type: Interventional

Intervention(s)

Irrigation group: Oral management and corticosteroid irrigation were carried out 4 times (treatment 1-4) with an interval of 7 (4-10) days.
Control group: Oral management was carried out 4 times (treatment 1-4) with an interval of 7 (4-10) days.

Outcome(s)

• Primary Outcome: xerostomia 4 weeks after treatment

Secondary Outcome

xerostomia on treatment 1-4
xerostomia on 4, 8,12 weeks after treatment
salivary flow rate on treatment 1-4
salivary flow rate 8,12 weeks after treatment

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 89age old
• Gender: Both

Include criteria

head and neck cancer patients receiving radiotherapy (IMRT) with dose greater than 50 Gy
One or more parotid and submandibular glands are included in the field of radiation.

• Exclude criteria: Patients with problem in judgement

Related Information

• Primary Sponsor: Takagi Yukinori