Feasibility study of postoperative adjuvant therapy using S-1 after curative esophagectomy for esophageal cancer

JRCT ID: jRCT1060220042

Registered date:09/07/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Esophageal cancer
• Date of first enrollment: 09/07/2022
• Target sample size: 45
• Study type: Observational

Outcome(s)

• Primary Outcome: Safety and feasibility of the administration of S-1 adjuvant chemotherapy for patients who underwent thoracoscopic esophagectomy with and without preoperative treatment.

Secondary Outcome

Overall Survival
Disease free survival
Adverse events due to S-1
Relative dose intensity

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Histologically confirmed esophageal squamous cell carcinoma or adenocarcinoma.
2) Postoperative adjuvant chemotherap using S-a was performed.
3) Curative gastrectomy was performed.
4) Performance status of 0-1 on the Eastern Cooperative Oncology Group classification
5) No prior chemotherapy, radiation, endcrine, molecular targeted therapy within 5 years including treatment for other cancers,
6) Sufficient oral intake.

Exclude criteria

(1)Double cancer
(2)Heart failure, hepatitis, renal dysfunction
(3)Severe infection

Related Information

• Primary Sponsor: Hirahara Noriyuki