Effects of tastant on salivation flow.

JRCT ID: jRCT1060210036

Registered date:01/10/2021

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Xerostomia
• Date of first enrollment: 01/10/2021
• Target sample size: 22
• Study type: Interventional
• Intervention(s): Sustained administration of tastant.The taste solutions are monosodium inosinate, monosodium glutamate, aspartame, sucralose, and acesulfame K. A very small amount of each solution(0.04ml/min) is dropped into the oral cavity for 120 minutes.

Outcome(s)

• Primary Outcome: Changes in saliva flow over time.
• Secondary Outcome: Subjective evaluation of taste intensity

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Healthy adults over 20 years old of Okayama University School of Dentistry and staff members of Okayama University Hospital
• Exclude criteria: Persons with a history of chemotherapy and radiation therapy for endocrine, immunological disease, liver damage, kidney damage or head and neck cancer and cold and Zinc deficiency and Those receiving medication that may have a direct effect on thirst and those who have saliva of 2g or less when stimulating the Saxon test.

Related Information

• Primary Sponsor: HIKARU SUGIMOTO