The research aboout the domain commonality and specificity between the motivational aberrant salience and psychiatric symptoms

JRCT ID: jRCT1052240225

Registered date:23/12/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Schizophrenia, Schizoaffective disorder, Delusional disorder, Bipolar Disorder, Depressive Disorder
• Date of first enrollment: 23/12/2024
• Target sample size: 100
• Study type: Interventional
• Intervention(s): Patient group and healthy control group: 7 Tesla MRI with cognitive tasks, 60 to 90 minutes per session

Outcome(s)

• Primary Outcome: Reaction speed, probability estimation, and fMRI-measured brain activity during the presentation of a modified Monetary Incentive Delay (MID) task
• Secondary Outcome: ASI, PDI, QPE, PLE, BIS/BAS and PANSS scores

Key inclusion & exclusion criteria

• Age minimum: >= 16age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

a) Patient group: Patients aged 16 years or older with schizophrenia (F2 in ICD-10, including schizophrenia, schizoaffective disorder, delusional disorder, etc.) and mood disorders (F3 in ICD-10, including bipolar disorder and depression)
b) Healthy control group: People aged 16 years or older who have not been diagnosed with any clear mental illness, including pre-existing conditions

Exclude criteria

Those with neurological disorders or disorders that affect the metabolism of the central nervous system
Those who are unable to give consent due to medical conditions, etc.
Those who meet the contraindications for MRI imaging

Related Information

• Primary Sponsor: Murai Toshiya
• Source(s) of Monetary Support: Japan Society for the Promotion of Science