NIPH Clinical Trials Search

JRCT ID: jRCT1052230134

Registered date:22/11/2023

Extra ablation beyond puLmonary vein Isolation Nurtures Elimination of atrial fibrillation, or not? (Ext-LINE) Study

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiedAtrial fibrillation
Date of first enrollment28/11/2023
Target sample size180
Countries of recruitment
Study typeInterventional
Intervention(s)In ExTRa mapping-guided ablation group, atrial sites of high %NP (mean %NP >35% and low voltage <0.5 mV ) were ablated and ExTRa mapping-guided anatomical line ablation was added after pulmonary vein isolation, and then electrical cardiversion was performed when sinus restoration was not obtained in 15 minutes after injection of Nifekalant 0.3mg/kg.


Primary OutcomeAtrial arrhythmia recurrence beyond 90 days after catheter ablation for atrial fibrillation
Secondary OutcomeCardiac function after procedure Atrial fibrillation-free survival, atrial tachycardia-fre e survival Atrial fibrillation termination rate Procedure detail (procedure time, ablation numbe r, ablation region) Adverse events Atrial arrhythmia recurrence beyond 90 days after repeat procedures

Key inclusion & exclusion criteria

Age minimum>= 21age old
Age maximum<= 90age old
Include criteriaFirst time ablation procedure for persistent atrial fibrillation Patients who can be followed for at least 1-year after procedure Patients from who we get written informed consent
Exclude criteriaPatients with AF termination only by pulmonary vein isolation Patients who received ablation procedure or MAZE procedure for for atrial fibrillation before enrollment

Related Information


Public contact
Name Tetsuma Kawaji
Address 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto Kyoto Japan 606-8507
Telephone +81-75-751-4254
Affiliation Affiliation Kyoto University Graduate School of M edicine
Scientific contact
Name Satoshi Shizuta
Address 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto Kyoto Japan 606-8507
Telephone +81-75-751-4254
Affiliation Kyoto University Hospital