A study of treatment of chronic pain with MSC-CM

JRCT ID: jRCT1051240003

Registered date:03/04/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Chronic Pain from knee osteoarthritis
• Date of first enrollment: 03/04/2024
• Study type: Observational

Outcome(s)

Primary Outcome

1. Effect of pain on daily life
2. Pain intensity (Numerical Rating Scale; NRS)
3. Kellgren-Lawrence grade

• Secondary Outcome: subjective symptoms, etc.

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Individuals who is diagnosed as knee osteoarthritis.
2. Those for whom satisfactory pain relief effects were not observed with standard therapy.
3. Individuals who do not wish to undergo treatment with drugs commonly used in standard therapy for chronic pain due to concerns about side effects, and have been deemed suitable for chronic pain treatment with conditioned medium by a physician.

The patient selection criteria are as follows:
<Inclusion Criteria>
Patients meeting the following criteria will be considered eligible:

1. Individuals aged 18 and above.
2. Individuals with normal decision-making capacity.
3. Individuals who have been provided with the informed consent document regarding this treatment, received sufficient explanation, and can provide voluntary written consent.
4. Individuals for whom the attending physician has recognized the necessity of treatment.

Exclude criteria

<Exclusion Criteria>
Individuals meeting any of the following conditions will be excluded from the study:
1. Individuals without pain other than nociplastic pain.
2. Patients with a history or suspicion of dementia
3. Users of narcotics or stimulants.
4. Individuals deemed inappropriate by the attending physician.

Related Information

• Primary Sponsor: Atsutomo Morishima