Remimazolam and desflurane for arterial oxygen partial pressure during unilateral lung ventilation : randomized controlled trial

JRCT ID: jRCT1051210194

Registered date:17/03/2022

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Lung tumor etc.
• Date of first enrollment: 09/06/2022
• Target sample size: 28
• Study type: Interventional
• Intervention(s): Use remimazolam or desflurane to maintain general anesthesia

Outcome(s)

• Primary Outcome: Minimum PaO2 value for 60 min after the start of unilateral lung ventilation

Secondary Outcome

The following measurements during bilateral lung ventilation and 15 min, 30 min, 45 min, and 60 min after the start of unilateral lung ventilation in the lateral position:
average blood pressure / pulse rate / cardiac output / SpO2 / EtCO2 / Etdes
arterial blood gas analysis results (pH / PaO2 / PaCO2)
total dose of remimazolam from induction of anesthesia

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 75age old
• Gender: Both

Include criteria

1.Patients scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation
2.American Society Association physical status class 1~3
3.Patients who have sufficient judgment to understand the research content and have provided written consent

Exclude criteria

Patients who meet any of the following conditions are excluded:
1.Scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation for less than 2 hours
2.Undergoing bilateral lung surgery
3.History of surgery on the ventilated lung
4.History of hypersensitivity to the following
ingredients of remimazolam
desflurane or other halogenated anesthetics
remifentanil components or fentanyl compounds
rocuronium component or bromide
5.History of drug dependence
6.History of malignant hyperthermia or a history of malignant hyperthermia in their relatives
7.Acute angle-closure glaucoma
8.Myasthenia gravis or Congenital myasthenia
9.Muscular dystrophy
10.Severe aortic regurgitation
11.Shock
12.Acute intoxication
13.Received nalmefene hydrochloride within the previous week
14.Continuously receiving antihypotensive agents
15.With a chest tube inserted
16. Interstitial pneumonia
17.Pregnant or breastfeeding
18.Arterial oxygen saturation (SpO2) of less than 95% in room air, or requiring oxygen administration
19.Severe liver dysfunction (serum bilirubin level >2.5 mg / dL or PT activity level <50%)
20.BMI of less than 15 kg/m2 or more than 30 kg/m2
21.QTc is greater than or equal to 450 msec (according to Bazett's correction formula) on preoperative electrocardiogram
22.Arrhythmia more than 3 times per minute on electrocardiogram

Related Information

• Primary Sponsor: Yamamoto Kasumi