JRCT ID: jRCT1051200078
Registered date:24/11/2020
Study on reduction of salivary virus by povidone iodine on COVID-19
Basic Information
| Recruitment status | Complete |
|---|---|
| Health condition(s) or Problem(s) studied | COVID-19 infection |
| Date of first enrollment | 30/11/2020 |
| Target sample size | 440 |
| Countries of recruitment | |
| Study type | Interventional |
| Intervention(s) | The intervention is a gargle or a water gargle with a 15-fold diluted gargle solution containing 7% gargle of povidone iodine. Povidone-iodine early gargle group was instructed to perform povidone-iodine gargle from the 2nd day to 6th day of treatment, and in povidone-iodine delayed gargle group, water gargle from 2nd to 4th day of medical treatment, and 5th and 6th day. Povidone Iodine is instructed to gargle. The gargle should be performed after waking up and before sampling, before lunch, before dinner, and before going to bed. |
Outcome(s)
| Primary Outcome | Among the subjects in which the virus was detected by RT-PCR of saliva samples on the 2nd day of accommodation treatment, the negative rate of SARS-CoV-2 virus by RT-PCR of saliva on the 5th day of accommodation treatment. |
|---|---|
| Secondary Outcome | Among the subjects in which the virus was detected by RT-PCR of saliva samples on the 2nd day of accommodation treatment, the negative rate of SARS-CoV-2 virus by RT-PCR of saliva on the 6th day of accommodation treatment. |
Key inclusion & exclusion criteria
| Age minimum | >= 16age old |
|---|---|
| Age maximum | Not applicable |
| Gender | Both |
| Include criteria | (1)Subjects who are 16 years old or older on the date of consent acquisition and who have obtained the consent of the substitute if they are 16 years old or older and less than 20 years old (2)Sex; male or female (3)quarantine at the hotel (4)Meets all of 1)-3) below 1) Subjects whose Asymptomatic/mild case has at least one RT-PCR test positive for SARS-CoV-2 from pharyngeal swab, nasopharyngeal swab or saliva. 2) Subjects who can gargle 3) Subjects who will be quarantined for 6days or more (5)Subjects who have obtained written consent voluntarily to participate in the trial |
| Exclude criteria | (1) Subjects who are on thyroid hormone preparation (2) Subjects who have Iodine allergy (3) Pregnant (4) Lactating female (5) Gargling with Povidone iodine before entry |
Related Information
| Primary Sponsor | Matsuyama Akifumi |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Osaka Prefectural Hospital Organization |
| Secondary ID(s) |
Contact
| Public contact | |
| Name | Akifumi Matsuyama |
| Address | 3-7-1,Habikino,Habikino-shi,Osaka Osaka Japan 583-8588 |
| Telephone | +81-729572121 |
| covid-19@ra.opho.jp | |
| Affiliation | Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization |
| Scientific contact | |
| Name | Akifumi Matsuyama |
| Address | 3-7-1,Habikino,Habikino-shi,Osaka Osaka Japan 583-8588 |
| Telephone | +81-729572121 |
| akifumi-matsuyama@umin.ac.jp | |
| Affiliation | Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization |