Short-term Prognosis in Liver Transplantation Perioperative Period with the Use of Synbiotics: An Observational Study

JRCT ID: jRCT1050240166

Registered date:22/10/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: end stage liver failure
• Date of first enrollment: 30/09/2024
• Target sample size: 30
• Study type: Observational

Outcome(s)

• Primary Outcome: Presence or absence of infection: Wound infection, cholangitis, pneumonia, urinary tract infection, intra-abdominal infection, sepsis, catheter infection, etc.

Secondary Outcome

Complications grade II or higher based on Clavien-Dindo classification
Postoperative liver damage (AST, ALT values)
Series of reactions (based on liver biopsy)
Early graft dysfunction (EAD)
Defecation frequency/characteristics of stool

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: <= 69age old
• Gender: Both

Include criteria

Patients who are 18 years of age or older at the time of informed consent
Cases who were clinically diagnosed as being suitable for liver transplantation and underwent living donor liver transplantation after the date of approval for this study.

Exclude criteria

Patients who have difficulty in oral intake
Patients with lactose allergy

Related Information

• Primary Sponsor: Uchida Yoichiro