Examination of the effects of renal rehabilitation treatment on kidney transplantation patients

JRCT ID: jRCT1050220180

Registered date:28/02/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Kidney Transplantation
• Date of first enrollment: 01/05/2023
• Target sample size: 30
• Study type: Interventional

Intervention(s)

Renal rehabilitation(aerobic exercise, resistance exercise, virtual reality training)
Cardio Pulmonary Exercise test
Body Composition Analyzer
Questionnaire for health related quality of life, and physical activities

Outcome(s)

• Primary Outcome: 6-minute walk distance

Secondary Outcome

Peak VO2(maximum VO2), Anaerobic Threshold
Gait Speed
Short Physical Performance Battery(as follows: SPPB)
Knee extension strength
eGFR, HGB, Alb
Echocardiography(left ventricular ejection fraction measured, left ventricular end diastolic diameter measured, left atrium diameter measured, left atrium volume measured, E/e' measured)
Ankle brachial pressure index/Pulse Wave Velocity(as follows: ABI/PWV)
Skeletal Muscle mass Index(as follows: SMI)
health-related quality of life, physical activities

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Patients who undergo kidney transplantation at the Department of Urology, Hyogo Medical University Hospital
2. Written informed consent from the patient for study participation
3. Age 20 or older at the time consent is obtained
4. Patients who understand and can parform renal rehabilitation treatment

Exclude criteria

1. Patient who refused renal rehabilitation treatment
2. Patients with acute myocardial infarction
3. Patients with poorly controlled unstable angina pectoris
4. Patients with poorly controlled arrhythmia
5. Patients with severe aortic stenosis
6. Patients with poorly controlled Heart failure
7. Patients with acute pulmonary embolism or pulmonary infarction
8. Patients with acute myocarditis or pericarditis
9. Patients with acute aortic dissection
10. Patients with mental illness who cannot communicate
11. Patients with poorly controlled hypertension (systolic blood pressure >= 180 mmHg, diastolic blood pressure >= 100 mmHg)
12. Patients with electrolyte imbalance (postoperative serum potassium >=5.5 mEq/L)
13. Patients who are judged unsuitable as subjects by the principal investigator or subinvestigator

Related Information

• Primary Sponsor: Domen Kazuhisa