Expression of metabolism-related genes in peripheral blood mononuclear cells in patients with dementia

JRCT ID: jRCT1050210166

Registered date:02/02/2022

Basic Information

• Recruitment status: Not Recruiting
• Health condition(s) or Problem(s) studied: dementia
• Date of first enrollment: 02/02/2022
• Target sample size: 20
• Study type: Observational

Outcome(s)

• Primary Outcome: Expression of metabolism-related genes in peripheral blood mononuclear cells

Secondary Outcome

1) Expression of metabolism-related genes in whole peripheral blood
2) MMSE (cognitive Function) Examination and Frailty Interview
3) Complete blood count and peripheral blood image (white blood cell composition)
4) Blood glucose level and HbA1c (sugar, energy metabolism)

Key inclusion & exclusion criteria

• Age minimum: >= 65age old
• Age maximum: Not applicable
• Gender: Male

Include criteria

1)disease: Elderly healthy people and dementia patients
Dementia patients must be diagnosed with probable Alzheimer's disease according to the NIA-AA Alzheimer's disease diagnostic criteria.
In the MMSE test, dementia patients should have a score of 23 or less, and the healthy group should have a score of 28 or more.
2)others: For patients with dementia, written consent must be obtained from a substitute other than the person himself (Do not exclude the acquisition of consent from the dementia patient).

Exclude criteria

1)Diabetes
2)During cancer disease treatment, less than 5 years after the end of cancer treatment
3)Thyroid disease
4)Infectious diseases (AIDS, hepatitis B, hepatitis C)
5)Fever at the time of blood collection
6)Chronic subdural hematoma
7)Normal pressure hydrocephalus
8)During hemodialysis (or doctors say the need for hemodialysis soon future)
9)COPD
10)During home oxygen therapy
11)Smoking within the last 12 months
12)Taking drugs that have a clear effect on the immune system, such as anti-cancer drugs, steroids, and anti-rheumatic drugs
13)Patients with serious complications, or those who have a history of these and are judged by the investigator and the investigator to be ineligible for this study
14)Others who are judged by the principal investigator and the investigator to be ineligible for this study

Related Information

• Primary Sponsor: Taguchi Akihiko
• Source(s) of Monetary Support: Kaneka Corporation