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JAPANESE
国立保健医療科学院
JRCT ID: jRCT1050210166

Registered date:02/02/2022

Expression of metabolism-related genes in peripheral blood mononuclear cells in patients with dementia

Basic Information

Recruitment status Complete
Health condition(s) or Problem(s) studieddementia
Date of first enrollment02/02/2022
Target sample size20
Countries of recruitment
Study typeObservational
Intervention(s)

Outcome(s)

Primary OutcomeExpression of metabolism-related genes in peripheral blood mononuclear cells
Secondary Outcome1) Expression of metabolism-related genes in whole peripheral blood 2) MMSE (cognitive Function) Examination and Frailty Interview 3) Complete blood count and peripheral blood image (white blood cell composition) 4) Blood glucose level and HbA1c (sugar, energy metabolism)

Key inclusion & exclusion criteria

Age minimum>= 65age old
Age maximumNot applicable
GenderMale
Include criteria1)disease: Elderly healthy people and dementia patients Dementia patients must be diagnosed with probable Alzheimer's disease according to the NIA-AA Alzheimer's disease diagnostic criteria. In the MMSE test, dementia patients should have a score of 23 or less, and the healthy group should have a score of 28 or more. 2)others: For patients with dementia, written consent must be obtained from a substitute other than the person himself (Do not exclude the acquisition of consent from the dementia patient).
Exclude criteria1)Diabetes 2)During cancer disease treatment, less than 5 years after the end of cancer treatment 3)Thyroid disease 4)Infectious diseases (AIDS, hepatitis B, hepatitis C) 5)Fever at the time of blood collection 6)Chronic subdural hematoma 7)Normal pressure hydrocephalus 8)During hemodialysis (or doctors say the need for hemodialysis soon future) 9)COPD 10)During home oxygen therapy 11)Smoking within the last 12 months 12)Taking drugs that have a clear effect on the immune system, such as anti-cancer drugs, steroids, and anti-rheumatic drugs 13)Patients with serious complications, or those who have a history of these and are judged by the investigator and the investigator to be ineligible for this study 14)Others who are judged by the principal investigator and the investigator to be ineligible for this study

Related Information

Contact

Public contact
Name Orie Saino
Address Institute of Biomedical Research and Innovation 5F, 2-2, Minatojima-Minamimachi, Chuo-ku, Kobe city Hyogo Japan 650-0047
Telephone +81-78-304-5772
E-mail saino.orie@fbri.org
Affiliation Foundation for Biomedical Research and Innovation at Kobe
Scientific contact
Name Akihiko Taguchi
Address Institute of Biomedical Research and Innovation 5F, 2-2, Minatojima-Minamimachi, Chuo-ku, Kobe city Hyogo Japan 650-0047
Telephone +81-78-304-5772
E-mail taguchi@fbri.org
Affiliation Foundation for Biomedical Research and Innovation at Kobe