FIbrosis Biomarker Mirroring Atrial fibRillation severity as a Key of aging (FIB-MARK) study

JRCT ID: jRCT1050200007

Registered date:27/04/2020

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: atrial fibrillation
• Date of first enrollment: 01/06/2019
• Target sample size: 250
• Study type: Observational

Outcome(s)

• Primary Outcome: The correlation between inflammatory biomarkers and fibrosis

Secondary Outcome

The change of serum Inflammatory biomarkers
The correlation between the inflammatory biomarkers and recurrent atrial tacyacrrhythmias
The correlation between the inflammatory biomarkers and clinical outcomes (death, heart failure, and stroke)

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 90age old
• Gender: Both

Include criteria

1) AF patients (receivinf voltage mapping during catheter ablation procedure in phase 1)
2) 20-90 years old
3)Patients who can follow beyond one year

Exclude criteria

1)Acute infection or intake of steroids
2)Invasive therapy within 3 months before procedure
3)Those with renal (estimated glomerular filtration ratio <30 ml/min/1.73m2)
4)Those with hepatic impairment
5)Those who previously received catheter ablation or MAZE procedure for AF
6)Inability to adhere to the study procedures.

Related Information

• Primary Sponsor: Kawaji Tetsuma
• Secondary Sponsor: Kimura Takeshi,JSPS KAKENHI JP19K17594