Effect of postoperative scheduled intravenous acetaminophen in patients undergoing lhead and neck tumor surgery

JRCT ID: jRCT1041230004

Registered date:08/04/2023

Basic Information

• Recruitment status: Not Recruiting
• Health condition(s) or Problem(s) studied: head and neck tumor
• Date of first enrollment: 20/04/2023
• Target sample size: 30
• Study type: Interventional

Intervention(s)

Intravenous infusion of acetaminophen every 6 hours after head and neck tumor surgery

Performed until 2 days after surgery Total 9-10 cycles

Outcome(s)

• Primary Outcome: Pain VAS score (on the day of surgery, postoperative days 1 and 2)
• Secondary Outcome: Length of hospital stay, postoperative oral intake (average of staple food and side dish), number of times of use of NSAIDs until postoperative day 2, adverse events

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

head and neck tumor
Surgery case under general anesthesia
20 years of age or older
Performance Status (ECOG) is 0 or 1
After obtaining informed consent for participation in the clinical research, the patient's voluntary written consent has been obtained

Exclude criteria

Patients with a history of allergy to acetaminophen in the past
Patients with aspirin asthma
Patients with liver dysfunction and thrombocytopenia
Patients who indicated their intention to refuse to participate before regular administration of Acerio
Patients who are judged to be unsuitable as subjects by the judgment of a doctor

Related Information

• Primary Sponsor: Endo Kazuhira
• Source(s) of Monetary Support: Grants-in-Aid for Scientific Research