Knee OA PET

JRCT ID: jRCT1041210110

Registered date:10/12/2021

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Osteoarthritis of knee joint
• Date of first enrollment: 10/12/2021
• Target sample size: 24
• Study type: Interventional
• Intervention(s): Intravenous fludeoxyglucose of 3.5 mSv/kg and walking load of 3.6 km/h for 20 min will be performed followed by PET-CT imaging.

Outcome(s)

• Primary Outcome: Skeletal muscle accumulation in PET images
• Secondary Outcome: none

Key inclusion & exclusion criteria

• Age minimum: >= 40age old
• Age maximum: < 70age old
• Gender: Both

Include criteria

1) Patients diagnosed with primary knee OA by X-ray evaluation
2) Patients who understand the study and can perform exercise on a treadmill
3) Patients who have given written consent of their own free will after giving full informed consent to participate in this study.

Exclude criteria

(1) Those who have been diagnosed and are undergoing treatment for diabetes or those who have an HbA1c of 6.5% or higher without treatment
2) Patients with a history of medical diseases (e.g. heart failure) that should be avoided during exercise
3) Patients with lower limb complaints except for knee joint pain
4) Those who have undergone PET scans in the past and have a history of allergy to the drug (18F-FDG)
(5) Those who are judged by the principal investigator or sub-investigator to be unsuitable as research subjects

Related Information

• Primary Sponsor: Junsuke Nakase