Metabolic changes by niacin (Niacin metabolism 4)

JRCT ID: jRCT1040240167

Registered date:16/01/2025

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: None
• Date of first enrollment: 16/01/2025
• Target sample size: 30
• Study type: Interventional
• Intervention(s): Nicotinamide

Outcome(s)

• Primary Outcome: Chenge in blood metabolite levels after taking supplement
• Secondary Outcome: Chenge in urinary metabolite levels after taking supplement

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Healthy individuals (men and women aged 40 years or older who do not suffer from any medical conditions requiring prescription medications).
2) Habitual drinkers (those who consume alcohol on four or more days per week, with a daily pure alcohol intake of 40g or more for men and 20g or more for women).
3) Individuals who can provide information regarding their usual alcohol consumption, including type, quantity, and frequency.
4) Individuals who have undergone a health checkup within the past year and can provide relevant information.
5) Individuals who have provided written consent based on their free will after receiving sufficient informed consent regarding participation in this study.

Exclude criteria

1) Individuals who are pregnant, breastfeeding, or may be pregnant.
2) Individuals who regularly consume medications or food products, including supplements, containing nicotinamide, nicotinic acid, NMN, or nicotinamide riboside (NR). However, those who have discontinued use at least five days before the study initiation may be eligible for participation, provided that the name of the medication or supplement and the date of discontinuation are recorded.
3) Individuals with a history of hypersensitivity to medications or food products containing nicotinamide, nicotinic acid, NMN, or NR.
4) Individuals who contract any illness during the study period.
5) Individuals deemed unsuitable for participation by the principal investigator or co-investigators for other reasons.

Related Information

• Primary Sponsor: Hirao Atsushi