Metabolic changes by niacin

JRCT ID: jRCT1040240067

Registered date:07/08/2024

Basic Information

• Recruitment status: Recruiting

Health condition(s) or Problem(s) studied

Chronic liver diseases
Cirrhosis

• Date of first enrollment: 07/08/2024
• Target sample size: 50
• Study type: Interventional
• Intervention(s): Single oral dose of nicotinamide

Outcome(s)

• Primary Outcome: Bood NAD+ related metabolite levels after taking supplement
• Secondary Outcome: Urinary NAD+ related metabolite levels after taking supplement

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Healthy subjects
2) Patients with chronic liver disease
3) Patients with cirrhosis
4) Individuals who have given their free and voluntary written consent to participate in the study after obtaining sufficient informed consent.

Exclude criteria

1) Pregnant, lactating, or possibly pregnant
2) Those taking medicines or supplements containing nicotine, nicotinic acid, or NMN.
3) Those with a history of hypersensitivity to medicines containing nicotine, nicotinic acid, or NMN, or to various foods containing nicotine, nicotinic acid, or NMN supplements.
4) Patients with severe hepatic decompensation classified as Child-Pugh Classification B or C
5) Those who are deemed inappropriate as research subjects by the Principal Investigator for other reasons.

Related Information

• Primary Sponsor: Hirao Atsushi